Key role identified for enzymes in DNA replication and sensitivity to chemotherapeutic drugs


Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials